About Betahistine H1 selective histamine analogue, diamine oxidase inhibitor, anti vertigo and in Meniere's syndrome. Mechanism of Action of Betahistine Betahistine is a histamine substitute. It produces vasodilatation and improves blood flow to the labyrinth and brain stem. There by it reduces the frequency of episodes of vertigo in patient with Meniere`s syndrome. It works directly on histamine receptors. These receptors are found in blood vessel walls including those in the ear. Activation of these receptors will results in the widening of blood vessels. This improves circulation reducing the pressure in the ear. Its main use is in treating Meniere`s disease. It helps in relieving the inner ear pressure and by reducing the frequency and severity of nausea and vertigo attacks. It also reduces tinnitus thus helping to restore normal hearing. Indications for Betahistine 1.Meniere`s syndrome 2.Vertigo