About Candesartan Cilexetil Angiotensin || Antagonist, Antihypertensive agent Mechanism of Action of Candesartan Cilexetil It is a antagonist of angiotensin 2 at AT-1 receptor.It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all actions of angiotensin-2 such as 1.Vasoconstriction,2. Central and peripheral sympathetic stimulus,3. Release of aldosterone and adrenaline,4. Salt and water reabsorption ,5.Central actions like thirst,vasopressin release, and growth promoting actions on heart and blood vessals Indications for Candesartan Cilexetil Hypertension Interactions for Candesartan Cilexetil Diuretics and other antihypertensives: Increased risk of hypotension Lithium: Increased lithium blood level NSAID: Decreased antihypertensive effect Potassium sparing diuretics, Potassium supplements: Increased risk of hyperkalemia