Mechanism of Action of Vitamin E Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation. Indications for Vitamin E 1. Vitamin E deficiency 2. Intermittent claudication 3. Nocturnal muscle cramps 4. Coronary artery disease 5. Fibrocystic breast disease 6. Cystic fibrosis 7. In premature infants exposed to high concentration of oxygen 8. As antioxidant Interactions for Vitamin E Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.