Glimet forte

  • Scientific Name: Glibenclamide 5mg.+ Metformin 800mg.
  • Dosage: 5/800mg
  • Type: Tablets
AED

Price: 18.48 Dirham

31/12/2025

    Medicine Description

    About Glimepiride Third-generation sulfonylurea, Oral Antidiabetic Agent. Mechanism of Action of Glimepiride It is a potent antidiabetic drug which exerts its action by increasing insulin release from the pancreas and by improving glucose tolerance. It acts on the "sulfonylurea receptors" on pancreatic ?-cell membrane and reduces conductance of ATP sensitive K+ channels and thus causes depolarization. This enhances Ca2+ influx and degranultion and thus increases insulin secretion rate at any glucose concentration. It primarily increases 2nd phase insulin secretion and has little effect on 1st phase. It also slows hepatic degradation of insulin and minor action of reducing glucagon release and increasing Somatostatin release. It also exerts stronger extrapancreatic action- by sensitizing the target tissues such as liver to insulin action. It increases the number of insulin receptors and through a post receptor action improving translation of receptor activation.
    you should ask your doctor before taking this medicine


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