About Oxytetracycline Tetracycline derivative, A broad spectrum antibiotic. Mechanism of Action of Oxytetracycline Oxytetracycline is a broad spectrum antibiotic which has action against both gram positive organisms & gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Oxytetracycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca & Mg and inhibits functioning of various enzymes & ribosome. Indications for Oxytetracycline 1.Pneumonia 2.Ophthalmic infections 3. Rickettsial infections 4.Psittacosis 5.Brucellosis 6.Sexually transmitted diseases like syphilis, gonorrhea, Chancroid 7.Urinogenital tract infections 8.In Lympho granuloma veneram 9.Gastrointestinal tract infections