About Minoxidil A potassium channel agonist,Direct-Acting Vasodilator, Hair- growth stimulant,In androgenic alopecia. Mechanism of Action of Minoxidil Minoxidil works by activating PGHS 1 (prostaglandin endoperoxide synthase-1) which helps promote hair growth. It enhances follicular size and results in thicker hair shafts and stimulates and prolongs the anagen phase of the hair cycle. This will results in longer and increased number of hairs. Indications for Minoxidil 1. Alopecia areata 2. Androgenic alopecia