Medicine Description
Indication For the treatment of schizophrenia and related psychotic disorders Pharmacodynamics Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 5HT2 and dopamine type 2 D2 receptors Quetiapine is an antagonist at serotonin 5HT1A and 5HT2 dopamine D1 and D2 histamine H1 and adrenergic alpha 1 and alpha 2 receptors Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors respectively Quetiapines antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug