About Nicotinamide Water Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid. Mechanism of Action of Nicotinamide Nicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile- reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels. Indications for Nicotinamide 1.Pellagra 2.Niacin deficiency 3.Hartnup disease Typical Dosage for Nicotinamide Pellagra: 200 to 500mg daily in divided doses. Prophylactically: 20 to 50mg daily. Dietary supplement: 10 to 20mg daily Hartnup disease: 50 to 200mg daily in divided doses.